ETH Zürich

Prof. Dr. François Diederich

ETH Zurich, Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, CH-8093 Zurich, Switzerland


Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.
Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Höffken HW, Seet M, Eisenreich W, Knölker HJ, Fischer M, Bacher A, Groll M, Diederich F.
Angewandte Chemie, International Edition Early View (2014)

5-Substituted (1-Thiolan-2-yl)cytosines as Inhibitors of A. aeolicus and E. coli IspE Kinases: Very Different Affinities to Similar Substrate-Binding Sites
Andri P. Schütz, Sebastian Locher, Bruno Bernet, Boris A. Illarionov, Markus Fischer, Adelbert Bacher, François Diederich
European Journal of Organic Chemistry 880-887 (2013)

Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site
Paolo Mombelli, Camille Le Chapelain, Noah Munzinger, Evelyne Joliat, Boris A. Illarionov, W. Bernd Schweizer, Anna K. H. Hirsch, Markus Fischer, Adelbert Bacher, François Diederich
European Journal of Organic Chemistry 1068-1079 (2013)

Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues
Andri P. Schütz, Sho Osawa, Jennifer Mathis, Anna K. H. Hirsch, Bruno Bernet, Boris A. Illarionov, Markus Fischer, Adelbert Bacher, Francois Diederich
European Journal of Organic Chemistry Early View (2012)

Lead discovery and optimization for IspD
Michael Seet, Matthias C. Witschel, Wolfgang Hoffken, Liliana Parra, Thomas Mietzner, Frank Thater, Ricarda Niggeweg, Franz Rohl, Boris A. Illarionov, Felix Rohdich, Johannes Kaiser, Markus Fischer, Adelbert Bacher, Francois Diederich
Abstracts of Papers, 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 19-23, 2012, MEDI-132 (2012)

Identification of 1,3-Diiminoisoindoline Carbohydrazides as Potential Antimalarial Candidates.
Paolo Mombelli; Matthias C. Witschel; Anthoni W. van Zijl; Julie G. Geist; Matthias Rottmann; Céline Freymond; Franz Röhl; Marcel Kaiser; Victoria Illarionova; Markus Fischer; Isabella Siepe; Bernd Schweizer; Reto Brun; François Diederich
ChemMedChem 7, 151-158 (2012)

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding
Matthias C. Witschel; H. Wolfgang Höffken; Michael Seet; Liliana Parra; Thomas Mietzner; Frank Thater; Ricarda Niggeweg; Franz Röhl; Boris Illarionov; Felix Rohdich; Johannes Kaiser; Markus Fischer; Adelbert Bacher; François Diederich
Angewandte Chemie, International Edition 50, 7931-7935 (2011)

Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum
Julie G. Geist; Susan Lauw; Victoria Illarionova; Boris Illarionov; Markus Fischer; Tobias Gräwert; Felix Rohdich; Wolfgang Eisenreich; Johannes Kaiser; Michael Groll; Christian Scheurer; Sergio Wittlin; Jose L. Alonso-Gomez; W. Bernd Schweizer; Adelbert Bacher; Francois Diederich
ChemMedChem 5, 1092-1101 (2010)

Prof. Dr. Gisbert Schneider

ETH Zurich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, CH-8093 Zurich


Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents
Daniel Reker, Michael Seet, Max Pillong, Christian P. Koch, Petra Schneider, Matthias C. Witschel, Matthias Rottmann, Céline Freymond, Reto Brun, Bernd Schweizer, Boris Illarionov, Adelbert Bacher, Markus Fischer, François Diederich, and Gisbert Schneider
submitted for publication